Testosterone Undecanoate Andriol Testocaps
Substance: Testosterone Undecanoate
Brand: MSD / Organon, India
Andriol Testocaps are used to replace the bodys natural sex hormone testosterone when not enough is made by the body. Testosterone Undecanoate, the active ingredient of Andriol Testocaps, is a white to creamy white crystalline powder.
In men testosterone is produced by the testicles. It is necessary for the normal growth, development and function of the male sex organs and for secondary male sex characteristics. It is necessary for the growth of body hair, the development of bones and muscles, and it stimulates the production of red blood cells. It also makes mens voices deepen. Andriol Testocaps containing testosterone are used to replace testosterone in a person who has low or no natural testosterone (a condition known as hypogonadism). Because of problems with the pituitary or testis, the production of testosterone by the body decreases.
Treatment of hypogonadal men with Andriol Testocaps results in a clinically significant rise of plasma concentrations of testosterone, dihydrotestosterone and androstenedione, as well as a decrease of SHBG (sex hormone binding globulin). In males with primary (hypergonadotropic) hypogonadism treatment with Andriol Testocaps results in a normalization of gonadotropin levels.
Following oral administration of Andriol Testocaps, an important part of the active substance Testosterone Undecanoate is coabsorbed with the lipophilic solvent from the intestine into the lymphatic system, thus circumventing the firstpass inactivation by the liver. During absorption Testosterone Undecanoate is partly reduced to dihydrotestosterone undecanoate. From the lymphatic system it is released into the plasma. In plasma and tissues both testosterone undecanoate and dihydrotestosterone undecanoate are hydrolyzed to yield the natural male androgens testosterone and dihydrotestosterone.
Testosterone has moderate anabolic properties but also is a powerful androgenic agent. Andriol Testocaps is taken orally at doses of 25-200 mg per day. However, the majority of bodybuilders do not see any effects at lower doses and even at doses of close to 400 mg/day, the effects are minimal at best.
When taken for more than 4-6 weeks, Andriol Testocaps can only slightly increase body mass and protein anabolism. However, for the body to build muscle one also has to eat a diet rich in calories. Most bodybuilders also take a combination of other hormones at the same time. Because testosterone is converted to estrogen in the fatty tissues, there is always the chance of developing gynecomastia and water retention. To prevent this, most bodybuilders add Arimidex or tamoxifen during the off cycle.
During Andriol Testocaps intake, the natural body testosterone release is inhibited by feedback mechanism through inhibition of pituitary LH. At large doses, even spermatogenesis can be impaired. To allow for the hypothalamic-pituitary axis to recover, it is highly recommended that Andriol Testocaps be tapered off slowly over a period of a few weeks. Sudden discontinuation of Andriol Testocaps can lead to extreme fatigue, weight loss and susceptibility to fractures.
Andriol Testocaps must be taken orally with the morning and evening meal. The capsules should be taken with some fluid and swallowed whole without chewing. If an uneven number of capsules are to be taken, the greater dose should be taken in the morning. The dosage of Andriol Testocaps should be determined by the physician according to the severity of the symptoms. The initial dose is usually 120-160 mg/day for 2-3 weeks. Subsequent dosage (40-120 mg/day) should be based on the clinical effect obtained in the first weeks of therapy. In general the dose of Andriol Testocaps should be adjusted according to the response of the individual patient.
The acute oral toxicity of testosterone undecanoate is very low. High dosages of Andriol Testocaps may cause gastrointestinal complaints due to the oily solvent contained in the capsule. Treatment may consist of emptying the stomach and supportive measures.
Side effects: acne, changes in your menstrual periods, male-pattern hair growth (such as on the chin or chest), male pattern baldness, enlarged clitoris, or increase or decrease in sex drive.
Less serious testosterone side effects may include: breast swelling in men, headache, anxiety, depressed mood, numbness or tingly feeling, or pain or swelling where the medicine was injected.
|Manufacturer||MSD / Organon, India|